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Exploring the Novel Value of PSMA PET in Sjögren's Syndrome: Integrated Analysis With Established FAPI PET Imaging
Sponsor: Peking Union Medical College Hospital
Summary
Primary Sjögren's syndrome (pSS) is a chronic autoimmune exocrinopathy characterized by lymphocytic infiltration, progressive destruction of salivary gland acini, and varying degrees of functional impairment and fibrosis. Conventional imaging provides limited ability to simultaneously evaluate glandular function and inflammatory activity, leading to challenges in disease staging and treatment decision-making. This study explores a conceptual dual-tracer imaging framework using PSMA PET and FAPI PET to delineate complementary biological processes in pSS.
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2025-09-01
Completion Date
2026-05-30
Last Updated
2026-01-07
Healthy Volunteers
No
Conditions
Interventions
⁶⁸Ga-PSMA PET/CT
PSMA PET imaging performed for clinical evaluation in prostate cancer patients, used as a comparator for physiologic salivary gland PSMA uptake.
⁶⁸Ga-FAPI PET/CT
FAPI PET imaging to assess inflammatory activity (FAPI) in patients with primary Sjögren's syndrome.
Locations (1)
Peking Union Medical College Hospital
Beijing, China