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Quantifying Motor Network Dynamics to Predict and Enhance Outcomes in Pediatric Dystonia
Sponsor: Children's Hospital Medical Center, Cincinnati
Summary
The goal of this study is to understand the development and progression of childhood dystonia, a movement disorder, in children. The main questions it aims to answer are: How does the activity of the neural network evolve in children with dystonia in the context of motor development? What are the effects of chronic and active stimulation on cortical and subcortical motor network function in children with deep brain stimulation (DBS)? Participants will: * Undergo noninvasive electrophysiological measurements (EEG, EMG) to quantify neural network activity. They will be tested at rest and during a simple motor reaction task. * Children with DBS will be assessed in the on and off DBS state to assess effects of chronic and active changes in motor network function.
Key Details
Gender
All
Age Range
6 Years - 21 Years
Study Type
INTERVENTIONAL
Enrollment
75
Start Date
2024-01-01
Completion Date
2029-12-31
Last Updated
2026-01-08
Healthy Volunteers
Yes
Interventions
DBS
Subjects with DBS will complete protocol with and without active stimulation
Locations (1)
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States