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ACTIVE NOT RECRUITING
NCT07325435
PHASE4

Beta Cell Function in Type 2 Diabetes: Differential Effects of SGLT2 Inhibitors and GLIP-Receptor Agonists

Sponsor: MaryAnn Banerji

View on ClinicalTrials.gov

Summary

Minorities have higher rates of diabetes, poorer glucose control, and higher complications and mortality rates than white people. Several recently approved diabetes medicines improve cardiovascular and renal outcomes through two different mechanisms. This study will explore key determinants of blood glucose levels namely beta cell function after short-term randomized, parallel group treatment with FDA approved Glucagon-Like Peptide-1 Receptor Agonists¬ (GLP-1 RA), or FDA approved Sodium-Glucose co-Transporter-2 Inhibitor (SGLT-2i). Because diabetes in black people shows a unique ability to recover pancreatic insulin secretion, it is important to determine whether the effects of these drug classes differentially improve pancreatic beta cell function.

Official title: Beta Cell Function in Type 2 Diabetes in Black Patients: Differential Effects of SGLT2 Inhibitors and GLIP-Receptor Agonists

Key Details

Gender

All

Age Range

24 Years - 80 Years

Study Type

INTERVENTIONAL

Enrollment

60

Start Date

2024-12-21

Completion Date

2028-06-30

Last Updated

2026-01-08

Healthy Volunteers

No

Interventions

DRUG

SGLT-2 inhibitor

SGLT-2 inhibitors block the SGLT-2 receptor

DRUG

GLP1-RA

GLP-1 RAs stimulate the GLP-1 Receptor

Locations (1)

SUNY Downstate Health Sciences University

Brooklyn, New York, United States