Clinical Research Directory
Browse clinical research sites, groups, and studies.
Licorice Extract Gel Versus Diode Laser for Physiologic Gingival Pigmentation
Sponsor: Alexandria University
Summary
This randomized controlled clinical trial aims to compare the effectiveness of topical licorice extract gel and diode laser (445 nm) in the treatment of physiologic gingival pigmentation. Twenty-four adult patients presenting with physiologic melanin pigmentation in the anterior esthetic zone of the maxillary or mandibular gingiva will be randomly allocated into two equal groups. One group will be treated with diode laser therapy, while the other group will receive topical licorice extract gel. Clinical outcomes will be assessed using standardized gingival pigmentation indices and patient satisfaction questionnaires over a follow-up period of 36 weeks.
Official title: A Comparative Evaluation of the Effectiveness of Topical Licorice Extract Gel and Diode Laser 445 nm on Physiologic Gingival Pigmentation
Key Details
Gender
All
Age Range
18 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
26
Start Date
2025-04-01
Completion Date
2026-01-01
Last Updated
2026-09-10
Healthy Volunteers
No
Conditions
Interventions
Diode Laser 445 nm
Gingival depigmentation performed using a diode laser with a wavelength of 445 nm in continuous wave mode at 1 W power.
Licorice Extract Gel
Topical licorice extract gel applied to pigmented gingival areas three times daily for one month, with continuation for a second and third month if required.
Locations (1)
Oral Medicine and Diagnosis Clinic, Faculty of Dentistry, Alexandria University
Alexandria, Alexandria Governorate, Egypt