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Antibiotics Distribution Study in Peripheral Compartments: Contribution of Microdialysis
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
Postoperative mediastinitis is an important cause of postoperative morbidity in children. The main objective of this study is to describe the distribution of cefazolin, using as surgical antibiotic prophylaxis, in the mediastinal compartment in children after cardiac surgery for congenital heart disease. The investigators aims to build a population pharmacokinetic model of cefazolin using plasma and tissue concentrations in order to optimize and individualize cefazolin dosing regimens. Cefazolin tissue pharmacokinetics will use a microdialysis procedure.
Official title: Cefazolin Distribution in Mediastinum After Heart Surgery in Children Using a Microdialysis Probe.
Key Details
Gender
All
Age Range
6 Months - 6 Years
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2026-01
Completion Date
2027-02
Last Updated
2026-01-08
Healthy Volunteers
No
Interventions
Microdialysis probe placement
Microdialysis probe is placed at the end of cardiac surgery in mediastinum and used during 36 hours for tissue samples until withdrawal.
Microdialysis and Plasma samples
26 Cefazolin Free tissue concentrations 6 total plasma concentrations
Locations (1)
Hôpital Necker Enfants Malades
Paris, Île-de-France Region, France