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Isoleucine Addition Treatment Effects in a Controlled Diet Study
Sponsor: Jean L. Fry
Summary
The primary purpose of this study is to determine whether isoleucine repletion attenuates increases in insulin sensitivity typically observed when people with obesity follow a healthy, low-isoleucine diet.
Official title: ISOLeucine Addition Treatment Effects (ISOLATE) in a Controlled Diet Study
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2026-05-04
Completion Date
2029-01-31
Last Updated
2026-03-12
Healthy Volunteers
No
Conditions
Interventions
L-Isoleucine
Participants will follow a habitual American style diet. All participants transition to a healthy, low-isoleucine diet the study team provides, but only the isoleucine group receives isoleucine supplements to replete the overall diet to typical intake levels.
Low-isoleucine diet
Healthy, weight-maintaining, low-isoleucine meals and snacks will be provided directly to participants for 4 weeks. Diets are formulated by registered dietitians to meet energy, protein, and amino-acid requirements while minimizing weight change; target macronutrient distribution ≈ 10% protein / 60% carbohydrate / 30% fat38. Isoleucine content will meet minimum needs of 23 mg/kg.
Locations (1)
University of Kentucky
Lexington, Kentucky, United States