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RECRUITING
NCT07329686
PHASE1/PHASE2

Clinical Study of Intrastromal Anti-VEGF Injection for Corneal Neovascularization.

Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

View on ClinicalTrials.gov

Summary

Corneal stromal injection is an emerging local drug delivery method, characterized by strong targeting, high drug concentration, and prolonged duration of action. It has been preliminarily applied in the treatment of fungal keratitis and neurotrophic corneal diseases. This study aims to investigate the safety and efficacy of anti-VEGF drugs delivered via corneal stromal injection in neovascularization caused by HSK (Herpes Simplex Keratitis). The study has clear medical significance and technical feasibility, and it is expected to promote innovation in the treatment paradigm for corneal neovascularization.

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

100

Start Date

2025-10-01

Completion Date

2026-10

Last Updated

2026-01-09

Healthy Volunteers

No

Interventions

DRUG

Intrastromal anti-VEGF injection and topical antiviral eye drops

The experimental group received intrastromal corneal injections of anti-VEGF (Vascular Endothelial Growth Factor) medication in conjunction with antiviral medication therapy

DRUG

Conventional antiviral topical ocular drops.

The control group was treated with conventional antiviral topical ocular drops.

Locations (1)

1 Xihu Avenue, Shangcheng District,Hangzhou, Zhejiang,China,Hangzhou, Zhejiang Completed

Hangzhou, Zhejiang, China