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First-Time-in-Human Study of GSK5471713 in Adults With mCRPC
Sponsor: GlaxoSmithKline
Summary
This first-time-in-human study will evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, preliminary clinical activity, and establish the benefit/risk of GSK5471713 given as a monotherapy in mCRPC.
Official title: A Phase 1/2 First-Time-in-Human, Open-label, Multicenter, Dose Escalation and Dose Optimization Study of GSK5471713 in Adult Participants With Metastatic Castration Resistant Prostate Cancer (mCRPC)
Key Details
Gender
MALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
54
Start Date
2026-02-10
Completion Date
2030-03-26
Last Updated
2026-02-19
Healthy Volunteers
No
Conditions
Interventions
GSK5471713
GSK5471713 will be administered at different dose levels based on the dose escalation study design
Locations (3)
GSK Investigational Site
Grand Rapids, Michigan, United States
GSK Investigational Site
West Valley City, Utah, United States
GSK Investigational Site
Montreal, Quebec, Canada