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Comparison of Intravenous Ondansetron and Low Dose Ketamine in Preventing Post Spinal Shivering
Sponsor: Mayo Hospital Lahore
Summary
This randomized controlled trial assessed whether intravenous ondansetron is more effective than low dose ketamine in preventing shivering after spinal anesthesia in adults undergoing elective surgery. Post spinal shivering is a frequent and uncomfortable complication of spinal anesthesia and may increase oxygen demand and interfere with routine monitoring. Adults aged 20 to 70 years (body weight 50 to 80 kg; American Society of Anesthesiologists class I to II) scheduled for elective procedures under standardized spinal anesthesia were randomly allocated in equal numbers to receive either ondansetron 8 mg intravenously or ketamine 0.25 mg/kg intravenously, administered 5 minutes after the spinal injection. Perioperative temperature management was standardized for all participants. The primary outcome was the occurrence of post spinal shivering during intraoperative monitoring. Among 180 participants, shivering occurred in 30.0% of those receiving ondansetron and 44.4% of those receiving ketamine, showing a statistically significant reduction with ondansetron.
Key Details
Gender
All
Age Range
20 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
180
Start Date
2020-07-01
Completion Date
2021-01-30
Last Updated
2026-09-16
Healthy Volunteers
No
Interventions
ondansetron
8 mg ondansetron administered intravenously as a single dose five minutes after spinal anesthesia.
Ketamine (0.25 mg/kg)
0.25 mg per kilogram ketamine administered intravenously as a single dose five minutes after spinal anesthesia.
Locations (1)
Mayo Hospital, Lahore
Lahore, Punjab Province, Pakistan