Clinical Research Directory
Browse clinical research sites, groups, and studies.
Prediction Model for MINS After Major Hepatobiliary Surgery
Sponsor: Beijing Tsinghua Chang Gung Hospital
Summary
This multi-center, prospective observational study aims to develop and validate an interpretable prediction model for Myocardial Injury After Noncardiac Surgery (MINS) in patients undergoing major hepatobiliary surgery. The study adopts a nested modeling strategy, starting with baseline risk factors (e.g., RCRI) and stepwise incorporating hepatic inflow occlusion strategies (specifically comparing SPVO vs. Pringle maneuver) and routine intraoperative biomarkers. The model's performance will be evaluated using AUC, Net Reclassification Improvement (NRI), and Decision Curve Analysis (DCA), followed by interpretability analysis using SHAP values and external validation in an independent cohort.
Official title: Development of an Interpretable Prediction Model for Myocardial Injury After Noncardiac Surgery in Patients Undergoing Major Hepatobiliary Surgery
Key Details
Gender
All
Age Range
18 Years - 85 Years
Study Type
OBSERVATIONAL
Enrollment
1800
Start Date
2025-06-11
Completion Date
2027-06-30
Last Updated
2026-01-12
Healthy Volunteers
No
Conditions
Interventions
Major Hepatobiliary Surgery
Patients undergo standard major hepatobiliary surgery (e.g., hepatectomy). The specific surgical strategy, including the method of hepatic inflow occlusion (e.g., Pringle maneuver or SPVO), is determined by the attending surgeon based on routine clinical practice and patient condition, not by the study protocol.
Locations (6)
Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine，Tsinghua University
Beijing, China
Peking University International Hospital
Beijing, China
The First Affiliated Hospital of Army Medical University
Chongqing, China
Qingdao West Coast New Area People's Hospital
Qingdao, China
The First Affiliated Hospital of Shandong First Medical University
Shandong, China
Zhuhai People's Hospital
Zhuhai, China