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Transcranial Magnetic Stimulation in Veterans With PTSD
Sponsor: White River Junction Veterans Affairs Medical Center
Summary
With this research investigators hope to begin to understand how rTMS can improve posttraumatic stress disorder (PTSD) symptoms. TMS improves PTSD through two interrelated mechanisms: change in brain limbic system function and change in systemic inflammatory activation. Participants who decide to join this study, will receive ten rTMS treatments. All participants will undergo a 40-minute rTMS procedure with a member of the study team 10 times over 2-4 weeks. Participants will undergo fMRI scans of the head in order to help researchers better understand potential effects of rTMS on brain activity. In addition, participants will be asked to give two breath and blood samples to look for signs of general inflammation.
Official title: Transcranial Magnetic Stimulation in Veterans With PTSD: A Pilot Study to Examine Mechanism of Effect
Key Details
Gender
All
Age Range
19 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2026-01-15
Completion Date
2027-01
Last Updated
2026-01-21
Healthy Volunteers
No
Conditions
Interventions
Transcranial Magnetic Stimulation
10 sessions of low frequency rTMS (1Hz) applied to the right dorsolateral prefrontal cortex.
Locations (1)
White River Junction VA Hospital
White River Junction, Vermont, United States