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Royal Jelly Supplementation in Unexplained Male Infertility
Sponsor: Medipol University
Summary
This randomized, double-blind, placebo-controlled clinical trial investigates the effects of oral Royal Jelly supplementation on sperm DNA fragmentation and pregnancy rates in couples with unexplained infertility. While routine semen analysis appears normal (normozoospermia) in these patients, underlying Sperm DNA Fragmentation (SDF) and oxidative stress are believed to contribute to reproductive failure. Participants will be randomized to receive either 750 mg of lyophilized Royal Jelly or a placebo daily for a period of 3 months (90 days). The study aims to evaluate whether the antioxidant properties of Royal Jelly can improve sperm chromatin integrity, reduce oxidative stress markers, and increase spontaneous pregnancy rates compared to the control group
Official title: Effect of Oral Royal Jelly Supplementation on Sperm DNA Fragmentation Index and Pregnancy in Couples With Unexplained Infertility: A Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Study
Key Details
Gender
MALE
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2026-02-01
Completion Date
2026-08-01
Last Updated
2026-01-13
Healthy Volunteers
No
Interventions
Lyophilized Royal Jelly
Participants will receive 750 mg of Lyophilized Royal Jelly capsules daily for 3 months (90 days).
Placebo
Participants will receive inert capsules identical in appearance and taste to the experimental drug daily for 3 months (90 days)