Inclusion Criteria:
* Thermal injury size 5-30% TBSA
* Admitted to the burn center and enroll able within 72 hours of injury
* Subject has two distinct areas of 100cm2 or larger of intermediate to deep partial thickness burns (study sites). These areas are judged to be comparable in depth.
* The subject and or caregiver is able and willing to follow the protocol requirements
* Achieve wound photos and dressing change at 3 days
Exclusion Criteria:
* Subject has congestive heart failure, oxygen-dependent chronic lung disease, end-stage renal disease, or liver cirrhosis
* Subject is undergoing hospice care.
* Subject is currently being treated for an active malignant disease
* Subject has other concurrent conditions that in the opinion of the Investigator may compromise subject safety
* Known contraindications to silver metals, silver chloride, or silver tetraoxide
* Known contraindications to lidocaine
* Known allergies to any components of either primary dressing in the study
* Known allergies to the silicone or adhesives in secondary dressings
* Burns located on the hands, feet, face, and/or genitals will be excluded from treatment sites, but will be included in the total TBSA calculation
* Subject has a combined TBSA of 31% or greater of partial and/or full thickness burn wounds
* Concurrent participation in another clinical trial that involves an investigational drug or device that would interfere with this study.
* Subject is pregnant, breast feeding, or planning to become pregnant.
* Subjects who, within 60 days prior to enrollment, have a history of more than two weeks treatment with immunosuppressants (including systemic corticosteroids \>10mg daily dose), cytotoxic chemotherapy, application of topical steroids within one month prior to enrollment, or who receive such medications during the screening period, or who are anticipated to require such medications during the course of the study.
* Burn study site(s) has been previously treated with tissue engineered materials (e.g., Apligraf® or Dermagraft®) or other scaffold materials (e.g., Oasis, Matristem) preceding the study wound dressing application.
* Burn study site(s) has been previously treated with a silvadene
