Inclusion Criteria:
* Participants aged 10 to 60 years;
* Informed consent can be obtained from the participant and/or their guardian;
* The participant and/or guardian are able to comply with the requirements of the clinical trial protocol.
Exclusion Criteria:
* Axillary temperature\>37.0°C on the day of vaccination
* History of rabies vaccination or use of rabies virus passive immunization preparations
* History of dog or other mammalian bites or scratches (with skin laceration) within 1 year prior to the first vaccination
* Abnormalities in laboratory tests such as complete blood count (CBC), blood biochemistry, and urinalysis before the first vaccination are clinically significant and cannot be excluded based on the investigator's comprehensive assessment.
* Suffering from acute illness or acute exacerbation of chronic disease within 3 days prior to the first vaccination
* Urinary pregnancy test results were positive in female participants of childbearing age, or they were in the lactation period, or female participants of childbearing age, male participants, or their partners had fertility plans during the trial period.
* History of severe allergic reactions requiring medical intervention or severe adverse reactions to vaccines (e.g., severe urticaria, anaphylactic shock, allergic laryngeal edema, Henoch-Schönlein purpura, localized allergic necrotic reaction (Arthus reaction), angioedema, etc.), or allergy to any component of the trial vaccine, such as human serum albumin, dextran 40, sucrose, glycine, disodium hydrogen phosphate, or potassium dihydrogen phosphate.
* Known or suspected malignancy, autoimmune disease, immunodeficiency, or immunosuppression (e.g., human immunodeficiency virus (HIV) infection, organ transplantation, systemic lupus erythematosus (SLE), rheumatoid arthritis, etc.)
* Within 6 months prior to the first dose or with a planned long-term use of immunosuppressants and/or immunomodulators (e.g., systemic glucocorticoids, continuous use of targeted immunomodulators for more than 14 days), cytotoxic therapy, etc.
* Patients with congenital malformations or developmental disorders affecting organ function, uncontrolled hypertension (limited to 18-60 years of age) \[maintained with medication at systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg\], severe hepatic or renal diseases (critical cases, e.g., with concomitant diabetes), etc.
* Contraindications to intramuscular injection, such as local infection or skin lesions at the injection site, severe thrombocytopenia, coagulation dysfunction, or a history of coagulation disorders
* History or family history of psychiatric and neurological disorders such as convulsions, epilepsy, encephalopathy, and psychosis
* Individuals who have received or plan to use blood products or immunoglobulin products during the trial period within the past 3 months
* Received other investigational drugs within 1 month prior to trial vaccine administration or was participating in other clinical trials
* Received a live attenuated vaccine within 14 days prior to enrollment, or a subunit or inactivated vaccine within 7 days prior to enrollment
