Clinical Research Directory
Browse clinical research sites, groups, and studies.
Steroid Use in Treatment of Allergic Reactions to Food
Sponsor: Johannes Trueck
Summary
In this study, the investigators want to find out whether a specific medication commonly used for severe allergic reactions is really necessary. When children have allergic reactions to foods, they are often given medications to relieve the symptoms. In addition to adrenaline and antihistamines, steroids are frequently administered in German-speaking Switzerland. However, it is unclear whether steroids are really helpful in this situation. To investigate this, the investigators are comparing two groups: one group receives additional steroids, and the other does not. Which treatment a participant receives is decided randomly, like flipping a coin. The study takes place during a pre-scheduled provocation test at the clinic. If an allergic reaction occurs, the usual emergency medications will be administered. Doctors will closely monitor how the reaction develops. No additional tests or visits are required. The results of this study could help improve allergy treatment in the future.
Official title: Evaluation of Emergency Medication in Children With Food Allergies: a Prospective, Randomized Clinical Multicenter Study Comparing Antihistamines Versus Antihistamines Plus Steroids in a Controlled Setting of Oral Food Challenges in Children.
Key Details
Gender
All
Age Range
6 Months - 18 Years
Study Type
INTERVENTIONAL
Enrollment
160
Start Date
2026-01-26
Completion Date
2026-12
Last Updated
2026-01-27
Healthy Volunteers
No
Interventions
Antihistamines
Oral administration of antihistamines for treatment of allergic symptoms during the oral food challenge.
Systemic corticosteroids
Oral administration of systemic corticosteroids as adjunctive treatment of allergic reactions during the oral food challenge.
Adrenaline (rescue medication)
Intramuscular administration of adrenaline as rescue treatment for severe allergic reactions (anaphylaxis), administered as clinically indicated.
Locations (2)
University Children's Hospital Basel
Basel, Basel, Switzerland
University Children's Hospital, Zürich
Zurich, Canton of Zurich, Switzerland