Clinical Research Directory

Inclusion Criteria: 1. Age above 50 years (including 50-year-old); 2. MRI confirmed the presence of typical imaging changes of CSVD; 3. Voluntary participation in the study and be willing to sign the Informed Consent Form. Exclusion Criteria: 1. Patients with acute ischemic stroke or acute intracranial hemorrhage (e.g., epidural hematoma, subdural hematoma, subarachnoid hemorrhage, intracerebral hemorrhage, etc.) or a history of cerebral infarction (non-lacunar) or intracranial hemorrhage within the past 3 months; 2. Significant non-vascular white matter lesions (e.g., multiple sclerosis, adult-onset leukoencephalopathy, metabolic encephalopathy, etc.); 3. Patients with a history of cognitive impairment due to other causes (e.g., normal pressure hydrocephalus, Alzheimer's disease, Parkinson's disease, multiple sclerosis, encephalitis, etc.); 4. Severe hepatic, renal, or cardiac insufficiency (ALT or AST \>2 times the upper limit of normal, or serum creatinine \>1.5 times the upper limit of normal, or New York Heart Association \[NYHA\] functional class III or IV); 5. Patients with psychiatric disorders that affect study medication administration and evaluation; 6. Contraindications to MRI examination (e.g., claustrophobia, presence of an implantable pacemaker, etc.); 7. Patients unable to comply with follow-up examinations or other study procedures due to residential location or other reasons; 8. Participation in other clinical trial projects.