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A Clinical Study to Evaluate the Effects of RO7875913 in Healthy Participants and of RO7875913 With Cevostamab in Participants With Relapsed/Refractory Multiple Myeloma
Sponsor: Genentech, Inc.
Summary
Part A: The purpose of Part A of this study is to evaluate the safety, pharmacokinetics, and pharmacodynamics of RO7875913 in healthy participants. Part B: The purpose of Part B of this study is to evaluate the safety, pharmacokinetics, pharmacodynamics, and preliminary clinical activity of RO7875913 administered in combination with the T cell-engaging bispecific antibody (TCB) cevostamab in participants with relapsed or refractory (R/R) multiple myeloma (MM).
Official title: A Phase Ia/Ib, Multicenter, Dose-Escalation and Expansion Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of RO7875913 in Healthy Volunteers and to Assess Its Preliminary Activity in Combination With Cevostamab In Patients With Relapsed Or Refractory Multiple Myeloma
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
240
Start Date
2026-03-11
Completion Date
2030-06-17
Last Updated
2026-09-30
Healthy Volunteers
Yes
Interventions
RO7875913
Participants will receive RO7875913 as per the schedule described in the protocol.
Placebo
Participants will receive placebo as per the schedule described in the protocol.
Cevostamab
Participants will receive cevostamab as per the schedule described in the protocol
Locations (1)
New Zealand Clinical Research - Christchurch
Christchurch, Canterbury, New Zealand