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ACTIVE NOT RECRUITING
NCT07342114
PHASE1

A Clinical Study to Evaluate the Effects of RO7875913 in Healthy Participants and of RO7875913 With Cevostamab in Participants With Relapsed/Refractory Multiple Myeloma

Sponsor: Genentech, Inc.

View on ClinicalTrials.gov

Summary

Part A: The purpose of Part A of this study is to evaluate the safety, pharmacokinetics, and pharmacodynamics of RO7875913 in healthy participants. Part B: The purpose of Part B of this study is to evaluate the safety, pharmacokinetics, pharmacodynamics, and preliminary clinical activity of RO7875913 administered in combination with the T cell-engaging bispecific antibody (TCB) cevostamab in participants with relapsed or refractory (R/R) multiple myeloma (MM).

Official title: A Phase Ia/Ib, Multicenter, Dose-Escalation and Expansion Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of RO7875913 in Healthy Volunteers and to Assess Its Preliminary Activity in Combination With Cevostamab In Patients With Relapsed Or Refractory Multiple Myeloma

Key Details

Gender

All

Age Range

18 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

240

Start Date

2026-03-11

Completion Date

2030-06-17

Last Updated

2026-09-30

Healthy Volunteers

Yes

Interventions

DRUG

RO7875913

Participants will receive RO7875913 as per the schedule described in the protocol.

DRUG

Placebo

Participants will receive placebo as per the schedule described in the protocol.

DRUG

Cevostamab

Participants will receive cevostamab as per the schedule described in the protocol

Locations (1)

New Zealand Clinical Research - Christchurch

Christchurch, Canterbury, New Zealand