Clinical Research Directory

Inclusion Criteria: 1. Age 2.00 months -17.99 years (prior to 18th birthday) 2. Confirmed or suspected diagnosis of orbital cellulitis as determined by the attending physician, medical team, and/or delegate's clinical judgement, based on one or more features of orbital cellulitis (i.e., ophthalmoplegia, pain and/or limitation with extraocular movements, chemosis, blurred vision, eye swollen shut, and/or proptosis). 3. Scheduled to be admitted or admitted to hospital for less than 36 hours. 4. Informed consent provided in accordance with institutional policies Exclusion Criteria: 1. Transferred directly from outside hospital inpatient setting to a participating hospital site's inpatient setting with over 36 hours having passed since admission to outside hospital. If within 36 hours, patient is eligible. 2. Treatment with IV or PO systemic corticosteroids within 1 week of presentation 3. Recent hospital admission for orbital cellulitis within 1 week of presentation 4. Current systemic fungal infection 5. Contraindication for dexamethasone or components of dexamethasone IV formulation 6. Clinically relevant varicella exposure in the previous 21 days 7. Previous enrollment in this study 8. No telephone/mobile/email 9. Poor mastery of English, or medical interpreter not available for languages other than English