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A Study Testing the Effects of Different THC Doses on Psychological and Biological Function
Sponsor: University of Calgary
Summary
The goal of this clinical trial is to learn how a investigational medicinal product (THC) affects psychological and physical responses in healthy adults with prior cannabis use experience. The main questions it aims to answer are: \- How do different dose levels of the investigational medicinal product (THC) influence short-term subjective and physiological responses? Researchers will compare three dose levels of the study drug to a placebo (a look-alike substance with no active ingredient) to see how responses vary across sessions. Participants will: * Attend four in-person study visits, each involving a single dose of either the study drug or placebo * Complete questionnaires about their moment-to-moment experiences * Have their heart rate, blood pressure, and other physical measures monitored * Undergo serial blood sampling to measure circulating biomarkers
Official title: Acute Dose-Dependent Effects of Oral THC on Physiological and Subjective Responses in Healthy Cannabis-Experienced Adults
Key Details
Gender
All
Age Range
18 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
24
Start Date
2026-02-01
Completion Date
2028-02-01
Last Updated
2026-01-16
Healthy Volunteers
Yes
Conditions
Interventions
AVCN319301b (6mg)
AVCN319301b is a standardized oral capsule containing a precise dose of Δ9-THC.
AVCN319301b (9mg)
AVCN319301b is a standardized oral capsule containing a precise dose of Δ9-THC.
AVCN319301b (15mg)
AVCN319301b is a standardized oral capsule containing a precise dose of Δ9-THC.
Placebo
The matched placebo is an oral capsule identical in appearance to the active study drug and contains the same non-medicinal ingredients but no Δ9-THC. It is manufactured to match the active capsules in size, color, taste, and packaging to maintain blinding for participants and study staff.
Locations (1)
University of Calgary, Heritage Medical Research Building
Calgary, Alberta, Canada