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Effects of DHA in Patients With Multiple Sclerosis
Sponsor: Francisco Javier Martínez Noguera
Summary
This clinical trial will investigate the effects of combining therapeutic exercise with DHA supplementation in 100 patients with multiple sclerosis using a randomized controlled design. Participants, diagnosed according to the McDonald criteria, will undergo functional, cognitive, fatigue, and quality-of-life assessments through tools such as the EDSS, BRB-N, MFIS, EVA-f, and MSQoL-54. Physiological evaluations will include infrared thermography, isokinetic strength testing, perceived exertion (Modified Borg Scale), balance (Timed Up and Go), lower-limb power (Sit-to-Stand app), and handgrip strength. The study hypothesizes that this combined intervention will improve motor function, cognition, fatigue management, and overall quality of life by enhancing neuromuscular activation and metabolic efficiency.
Official title: Effects of Therapeutic Exercise and Long-term Docosahexaenoic Acid (DHA) Supplementation on Physical, Physiological, Motor, Mental, and Cognitive Variables in Patients With Multiple Sclerosis.
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2026-01
Completion Date
2026-07
Last Updated
2026-01-16
Healthy Volunteers
Yes
Conditions
Interventions
Docosahexaenoic Acid (DHA) Dietary Supplement
Subjects will take 2 g of DHA per day for 3 months.
Docosahexaenoic Acid (DHA) Dietary Supplement
Subjects will take 2 g of DHA per day + therapeutic exercise (3 times a week) for 3 months.
Sunflower Oil
Subjects will take 2 g of placebo (sunflower oil) per day for 3 months.
Sunflower Oil
Subjects will take 2 g of placebo per day + therapeutic exercise (3 times a week) for 3 months.
Locations (1)
Research Center for High Performance Sport. Universidad Católica de Murcia
La Ñora, Murcia, Spain