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Electrophysiology-based DBS Programming for PD
Sponsor: University of Florida
Summary
Deep brain stimulation (DBS) effectively alleviates motor symptoms in Parkinson's disease (PD). However, current programming is manual and time-consuming. This study will evaluate physiology-based programming using local field potentials (LFPs) to identify optimal stimulation parameters. Specifically, DBS contact selection based on beta power and a broad-band approach will be compared with conventional clinician-based programming.
Official title: Electrophysiology-based Deep Brain Stimulation Programming for Parkinson's Disease
Key Details
Gender
All
Age Range
21 Years - 89 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2026-01-15
Completion Date
2031-01-15
Last Updated
2026-03-30
Healthy Volunteers
No
Conditions
Interventions
Clinician-based DBS programming
Contacts, amplitude, pulse width, and frequency are chosen by the treating physician during a conventional monopolar review.
Maximum Beta power-based DBS programming
The contact that shows the strongest beta activity (13-30 Hz) in the local field potentials is selected for stimulation.
Broad-band electrophysiology-based DBS programming
A multi-frequency algorithm that integrates beta, theta/alpha, finely tuned gamma, and other relevant bands is used to identify the optimal contact.
Locations (1)
Norman Fixel Institute for Neurological Diseases
Gainesville, Florida, United States