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Dilute Epinephrine vs Tourniquet for Visualization in Ankle Arthroscopy: A RCT
Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Summary
This multicenter, prospective randomized controlled trial investigates the effect of dilute epinephrine irrigation versus tourniquet use on visual field clarity (VFC) during ankle arthroscopy. Patients are randomized into an epinephrine group (normal saline with 1 mL of 1:1000 epinephrine per 3 L bag; tourniquet placed but not inflated unless needed) or a standard tourniquet group. The primary outcome is arthroscopic visual field clarity assessed using a 4-point Likert-style numeric rating scale. Secondary outcomes include postoperative pain intensity at 2 and 24 hours (VAS), and the incidence of hypotension, bradycardia, and cardiovascular adverse events.
Official title: The Effect of Dilute Epinephrine Saline Irrigation on Field Clarity in Ankle Arthroscopic Surgery Compared to a Tourniquet: a Double-blind, Randomized Controlled Trial
Key Details
Gender
All
Age Range
15 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
88
Start Date
2025-12-30
Completion Date
2026-12-30
Last Updated
2026-01-16
Healthy Volunteers
No
Interventions
Epinephrine group
Irrigation fluid consisted of normal saline mixed with 1 mL of 1:1000 epinephrine per 3-liter bag. A tourniquet was placed but left deflated as a rescue measure and could be inflated intraoperatively if necessary.
Tourniquet group
Standard tourniquet application