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Sodium Supplementation and Growth in Premature Neonates
Sponsor: Ain Shams University
Summary
Primary aim: to assess the impact of late (≥7 days postnatal) sodium supplementation of premature neonates with birth weight less than 2500 gm on their postnatal short-term catch-up growth. Secondary aim: to find out the effect of this sodium supplementation on fractional excretion of sodium, hemodynamics and prematurity-related short-term neonatal outcomes including morbidities and morality.
Official title: Impact of Sodium Supplementation on Postnatal Growth of Premature Neonates: a Randomised Controlled Clinical Trial
Key Details
Gender
All
Age Range
7 Days - 28 Days
Study Type
INTERVENTIONAL
Enrollment
74
Start Date
2025-11-06
Completion Date
2028-12-30
Last Updated
2026-01-20
Healthy Volunteers
Yes
Interventions
Sodium supplementation guided by serum sodium and fraction sodium in urine
The Study population will be stratified according to gender and gestational age and randomly assigned into 2 groups: * Group A: will receive sodium supplementation with a moderate dose (4 mEq/kg/day) above basic maintenance requirements starting from 7 days to 28 days after birth. Sodium will be supplemented in the form of hypertonic saline provided either parenteral (added to maintenance intravenous fluid) or enteral, if oral intake exceeds 100 ml/kg/day (divided and added to feds every 6 hours) \[9\] (withhold supplementation if the serum sodium reaches 150 mmol/L, or development of vomiting or diarrhea with oral supplementation). * Group B: control group will receive basic maintenance requirements of the sodium supplementation (3mEq/kg/day).
Locations (1)
Eldemerdash Hospital
Cairo, Egypt