Clinical Research Directory

Inclusion Criteria: 1. 18 years of age or older. 2. American Society of Anesthesiologists (ASA) Physical Classification Status I-III. 3. Scheduled to undergo unilateral elective primary total knee arthroplasty for advanced osteoarthritis of the knee. 4. Access to a device running iOS Version 10.0 or above, or Android Version 5.0 or above that can connect to the internet. Exclusion Criteria: 1. History of brain surgery, central nervous system tumors, seizures (including epilepsy), stroke or intracranial implants (e.g plates, screws, deep brain stimulators) 2. Have vascular, traumatic, infectious, or metabolic lesions or diseases of the brain 3. Active diagnosis of a sleep disorder, defined as a documented diagnosis of any of the following conditions within the past 12 months, based on patient history or medical record review: * Insomnia disorder (e.g., difficulty initiating or maintaining sleep, early morning awakening) * Obstructive sleep apnea (OSA) * Central sleep apnea * Narcolepsy * Restless legs syndrome * REM sleep behavior disorder * Circadian rhythm sleep-wake disorders * Parasomnias (e.g., sleepwalking, night terrors) 4. Active diagnosis of alcohol use disorder, defined as meeting DSM-5 criteria or documented in the patient's medical record within the past 12 months. 5. Patients taking opioid medications with a daily Oral Morphine Equivalent (OME) of ≥ 80 mg 6. Current use of medications or substances known to alter cortical excitability or possess psychoactive properties (e.g., antiepileptics, benzodiazepines, antidepressants, antipsychotics, hallucinogens, dissociatives), as determined by review of the patient's medication list, chart review, and patient history. This includes prescribed medications and illicit substances used within the past 30 days. 7. Have metallic implants or objects in or on the head, including mouth (e.g. electrodes, stents, clips, pins, braces, shrapnel, jewellery (unremovable) 8. Use passive or active implanted medical devices (e.g., pacemakers, defibrillators, cochlear implants, natural implants or active body-worn medical devices (e.g., neural stimulation or medication infusion devices) 9. Have defects in the neurocranium (e.g., post-skull trepanation) 10. Have large vessel occlusions (e.g., complete blockage of the internal carotid artery or other conditions affecting brain perfusion 11. Have skin diseases of the scalp 12. Are using other brain stimulation devices concurrently 13. Are pregnant 14. Are unable to provide informed consent 15. Are unable to wear or tolerate the study device 16. Unable to speak or read English, or understand device operation instructions