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NOT YET RECRUITING
NCT07353658
NA

Effect of Intermittent Enteral Feeding in Severe Stroke

Sponsor: Xijing Hospital

View on ClinicalTrials.gov

Summary

This is a single-center, randomized, exploratory clinical trial investigating whether intermittent enteral feeding improves outcomes compared to continuous feeding in patients with severe stroke. The study will enroll 60 patients to evaluate the impact on 90-day all-cause mortality, neurological function, nutritional status, and safety. It will also explore underlying mechanisms through analysis of metabolic profiles, circadian gene expression, and gut microbiota.

Official title: The Effect of Intermittent Versus Continuous Enteral Feeding on Outcomes in Severe Stroke: An Exploratory Study

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

60

Start Date

2026-01-05

Completion Date

2026-12-31

Last Updated

2026-01-20

Healthy Volunteers

No

Interventions

BEHAVIORAL

Intermittent Enteral Feeding

Participants randomized to this group will receive enteral nutrition via a nasogastric or nasojejunal tube using an intermittent, daytime-only feeding schedule designed to align with the physiological circadian rhythm.

BEHAVIORAL

Continuous Enteral Feeding

Participants randomized to this group will receive enteral nutrition via a nasogastric or nasojejunal tube using the standard, continuous 24-hour feeding method commonly employed in critical care settings.