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DemonsTTRate: A Global, Observational, Multicenter, Long-term Study of Patients With ATTR-CM in a Real-World Setting
Sponsor: Alnylam Pharmaceuticals
Summary
The purpose of this study is to: * Describe the clinical characteristics of adult patients with transthyretin-mediated amyloidosis with cardiomyopathy (ATTR-CM) treated with vutrisiran in routine clinical care * Describe treatment patterns of adult patients with ATTR-CM treated with vutrisiran in routine clinical care * Assess health-related quality of life (HRQOL) in adult patients with ATTR-CM treated with vutrisiran in routine clinical care * Assess healthcare resource use (HCRU) in adult patients with ATTR-CM treated with vutrisiran in routine clinical care * Compare the long-term effectiveness of vutrisiran versus other approved ATTR-CM treatments in routine clinical care
Official title: DemonsTTRate: A Global, Observational, Multicenter, Long-term Study of Patients With Transthyretin-Mediated Amyloidosis With Cardiomyopathy in a Real-World Setting
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
2000
Start Date
2026-01-09
Completion Date
2030-10-23
Last Updated
2026-10-09
Healthy Volunteers
No
Locations (27)
Clinical Trial Site
Tucson, Arizona, United States
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Beverly Hills, California, United States
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La Jolla, California, United States
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Naples, Florida, United States
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Honolulu, Hawaii, United States
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Kansas City, Kansas, United States
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Boston, Massachusetts, United States
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St Louis, Missouri, United States
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New Brunswick, New Jersey, United States
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Charlotte, North Carolina, United States
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Philadelphia, Pennsylvania, United States
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Memphis, Tennessee, United States
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Dallas, Texas, United States
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Heidelberg, Germany
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Munich, Germany
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Münster, Germany
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Würzburg, Germany
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Bunkyō City, Japan
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Kumamoto, Japan
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Kurume, Japan
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Matsumoto, Japan
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Sendai, Japan
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Shinjuku, Japan
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Suita, Japan
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Tsukuba, Japan
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Ube, Japan
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Yufu, Japan