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NCT07358676

PHASE2

A Study of Bemotuzumab Plus Chemotherapy and Anlotinib Induction Followed by Bemotuzumab, Anlotinib and Consolidative Thoracic Radiotherapy in Extensive-Stage Small Cell Lung Cancer

Sponsor: Tianjin Medical University Cancer Institute and Hospital

View on ClinicalTrials.gov

Summary

This is a phase II study evaluating a new combination therapy for untreated extensive-stage small cell lung cancer. The treatment involves an initial phase with the drug Bemotuzumab plus standard chemotherapy and anlotinib, followed by a phase combining Bemotuzumab, anlotinib, and chest radiation. The primary objectives are to assess the efficacy of this approach in delaying cancer growth (progression-free survival) and to evaluate its safety in approximately 25 patients.

Official title: An Exploratory Phase II Study of Bemotuzumab Combined With Chemotherapy and Anlotinib as Induction Therapy, Followed by Bemotuzumab, Anlotinib, and Consolidative Thoracic Radiotherapy in Patients With Extensive-Stage Small Cell Lung Cancer

Key Details

Gender

All

Age Range

18 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

Start Date

2026-02-01

Completion Date

2028-01-01

Last Updated

2026-01-22

Healthy Volunteers

Conditions

Small Cell Lung Cancer (SCLC)SCLC, Extensive Stage

Interventions

COMBINATION_PRODUCT

Bemotuzumab + Anlotinib + Chemotherapy + Radiotherapy

This is a multi-phase combined modality regimen. Induction Phase (4 cycles): Bemotuzumab (1200mg IV, Day1 q3w) + Platinum/Etoposide chemotherapy (Carboplatin \[AUC5\] or Cisplatin \[75-80 mg/m²\] on Day1, plus Etoposide \[100 mg/m² IV, Days1-3\]) + oral Anlotinib (12mg, Days1-14, then 7 days off). Consolidation Phase (2 cycles): Bemotuzumab (same dose) + Anlotinib (same schedule) + concurrent Thoracic Radiotherapy (5 Gy per fraction for 5 fractions). Maintenance Phase: Bemotuzumab (q3w) + Anlotinib until disease progression or unacceptable toxicity. Anlotinib Dose Modification: The dose may be increased to 12mg if well tolerated. For toxicity, it can be reduced sequentially (12mg→10mg→8mg). Treatment is discontinued if 8mg is not tolerated. For subjects at 8mg, one dose re-escalation is permitted if, in the investigator's judgement, clinical benefit is possible and safety is stable.

\*\*Inclusion Criteria:\*\* 1. Histologically or cytologically confirmed extensive-stage small cell lung cancer (ES-SCLC) per VALG staging. 2. No prior systemic therapy for ES-SCLC. 3. At least one measurable lesion as defined by RECIST 1.1 criteria. 4. Age 18-75 years. 5. ECOG performance status of 0-2. 6. Life expectancy of ≥3 months. 7. Adequate hematologic and organ function: * Absolute neutrophil count (ANC) ≥ 1.5 × 10\^9/L. * Platelet count ≥ 100 × 10\^9/L. * Hemoglobin ≥ 80 g/L. * Creatinine clearance ≥ 50 mL/min. * Total bilirubin ≤ 1.5 × upper limit of normal (ULN). * AST and ALT ≤ 2.5 × ULN. * Albumin ≥ 28 g/L. * INR and APTT ≤ 1.5 × ULN. * Left ventricular ejection fraction (LVEF) ≥ 50%. 8. For females of childbearing potential: negative serum pregnancy test within 3 days prior to dosing and agreement to use highly effective contraception. 9. For males: agreement to use barrier contraception. 10. Willing and able to provide written informed consent and comply with study procedures. \*\*Exclusion Criteria:\*\* 1. Symptomatic brain metastases. (Asymptomatic, treated, and stable brain metastases for ≥1 month without steroids are allowed). 2. Prior thoracic radiotherapy for SCLC. 3. Prior treatment with anti-angiogenic agents (e.g., anlotinib, bevacizumab) or anti-PD-1/PD-L1 therapies. 4. Factors affecting oral medication intake (e.g., inability to swallow, major gastrointestinal resection). 5. Uncontrolled effusions requiring repeated drainage (pleural, pericardial, or ascites). 6. Imaging evidence of tumor invasion of major blood vessels or high risk of fatal hemorrhage as judged by the investigator. 7. History of significant bleeding tendency or coagulopathy, including clinically significant hemoptysis (\>1 tablespoon daily within 3 months) or significant bleeding within 4 weeks prior to enrollment. 8. Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to enrollment. 9. Arterial/venous thrombotic events within 6 months prior to enrollment (e.g., cerebrovascular accident, deep vein thrombosis, pulmonary embolism). 10. Active autoimmune disease requiring systemic treatment within 2 years prior to first dose. 11. Any other condition that, in the investigator's judgment, increases risk or renders the patient unsuitable for the study.

Locations (1)

Tianjin Medical University Cancer Institute & Hospital

Tianjin, Tianjin Municipality, China