Clinical Research Directory

Inclusion Criteria: * Person after signing informed consent. * After meeting the valid diagnostic criteria for the given neurological diagnosis. * Possession of a valid driver's license and proof of active driving. * Age limit 18 - 85 years. Exclusion Criteria: * Proven diagnosis of dementia based on a current psychological examination (MMSE 24 points or less). * Diagnosis of a disease or condition that, according to Czech Law. No. 277/2004 Coll., on medical fitness to drive motor vehicles, as amended (especially Law No. 204/2025 Coll.), prevents or significantly limits the ability to drive a motor vehicle safely (e.g. dementia, epilepsy, severe disorders of consciousness). * Age less than 18 years. * Age more than 85 years. * In the second cohort (patients with Multiple Sclerosis), proven and treated relapse in the last 6 weeks before inclusion in the study. * In the MS cohort, current EDSS \> 6.5 points. * For the PD cohort, the current Hoehn and Yahr scale score is greater than or equal to 4. * For both cohorts, evidence of parainfectious deterioration as demonstrated by laboratory testing.