Clinical Research Directory

Inclusion Criteria: 1. Male or female ages 18 to 55. 2. An Institutional Review Board (IRB) approved informed consent is signed and dated prior to any study-related activities. 3. Baseline core body temperature between 36.8℃ and 37.5℃. 4. Have the ability to understand the requirements of the study and are willing to comply with all study procedures. 5. In the opinion of the Investigator, are able to participate in the study. Exclusion Criteria: 1. History of cardiovascular, respiratory, or metabolic disorder 2. Any contraindication to undergoing Magnetic Resonance Imaging (MRI) 3. Pregnant 4. Severe peripheral vascular disease 5. History of Raynaud's disease 6. Currently experiencing a respiratory infection 7. Chronic rhinosinusitis 8. History of sickle cell disease 9. History of cold agglutinin disease 10. History of cryoglobulinemia 11. Known deviated septum or nasal deformity 12. History of nosebleeds or a nosebleed within past 24 hours 13. Use of antipyretics or other medications affecting body temperature within the past 24 hours.