Clinical Research Directory

Inclusion Criteria: * Eligible participants are 1. adults aged 18 to 65, 2. currently admitted to a transitional living program for opioid use and within the first 30 days of admission 3. voluntarily agree to participate and demonstrate adequate decision-making capacity as determined by the study team during informed consent 4. able to read and speak English, 5. have a clinical diagnosis of OUD at any severity level, whether mild, moderate, or severe, 6. identify opioids as their primary drug of choice 7. should have access to smartphones for daily individual practice of the intervention. 8. must reside at the treatment program for the duration of the study Exclusion Criteria: 1. inability to provide informed consent, 2. inability to demonstrate adequate decision-making capacity 3. currently having suicidal thoughts or psychotic symptoms 4. history of receiving previous HRVB training, 5. have a serious cardiac condition such as having pacemaker, heart failure or cardiac arrhythmia), 6. a known self-reported diagnosis of dementia, a severe brain injury, or a serious neurological condition(e.g., Parkinson's disease) 7. currently enrolled in any other biofeedback program simultaneously 8. currently taking medications such as MAOIs and alpha/beta blockers or benzodiazepines. Participant recruitment will be conducted at the recruitment site. Individuals younger than 18 or older than 65 years are excluded from participation primarily due to age-related differences in autonomic function and heart rate variability (HRV) regulation. Restricting the sample to adults aged 18-65 allows for more accurate measurement and interpretation of HRV data, thereby reducing potential confounding effects related to age-related physiological differences.