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A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate to Severe Chronic Obstructive Pulmonary Disease
Sponsor: Pfizer
Summary
The purpose of this clinical trial is to learn about the effects and safety of the study medicine PF-07275315 for the potential treatment of COPD. COPD is a condition that makes it difficult to breathe, which negatively impacts the quality of life and functioning of people who are affected. This study is seeking participants who: * Are 35 to 80 years old * Have had moderate-to-severe COPD for at least 12 months * Have a documented history of at least 2 moderate or severe exacerbations within the last 12 months * Have been continuously taking their regular maintenance treatment(s) for COPD over at least 6 months at a stable dose for 3 months All participants will receive PF-07275315 or a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. PF-07275315 or placebo will be given as multiple shots in the clinic over the course of 24 weeks for the Phase 2 part and 52 weeks for the Phase 3 part. We will compare the results of people receiving PF-07275315 to those of the people who do not. This will help us determine if PF-07275315 is safe and effective. Participants who will be involved in the Phase 2 part of the study for about 40 weeks. During this time, they will have 11 visits at the study clinic. Participants who will be involved in the Phase 3 part of the study for about 68 weeks. During this time, they will have 18 visits at the study clinic.
Official title: AN INTERVENTIONAL PHASE 2/3, RANDOMIZED, DOUBLE-BLIND, THIRD PARTY-UNBLINDED, PLACEBO-CONTROLLED, PARALLEL-GROUP STUDY TO INVESTIGATE EFFICACY AND SAFETY OF PF-07275315 IN ADULT PARTICIPANTS WITH MODERATE-TO-SEVERE CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)
Key Details
Gender
All
Age Range
35 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
1156
Start Date
2026-02-11
Completion Date
2031-01-16
Last Updated
2026-03-27
Healthy Volunteers
No
Interventions
PF-07275315 dose 1
SC injection dose 1
PF-07275315-dose 2
SC injection dose 2
Placebo
SC injection matched
PF-07275315-dose 3
SC injection dose 3
Locations (32)
SEC Clinical Research
Dothan, Alabama, United States
Pulmonary Associates of Mobile, P.C.
Mobile, Alabama, United States
Chandler Clinical Trials
Chandler, Arizona, United States
Pulmonary Associates, PA
Phoenix, Arizona, United States
IMAX Clinical Trials
La Palma, California, United States
NewportNativeMD, Inc.
Newport Beach, California, United States
California Medical Research Associates
Northridge, California, United States
Institute of HealthCare Assessment d/b/a Apex Clinical Research
San Diego, California, United States
Advanced Pulmonary Research Institute
Loxahatchee Groves, Florida, United States
Reed Medical Research
Miami, Florida, United States
Coastal Medical Research Institute, LLC
St. Petersburg, Florida, United States
Coastal Pulmonary and Critical Care, P.L.C
St. Petersburg, Florida, United States
Cpcc-Research Llc
East Point, Georgia, United States
Centricity Research Rincon Pulmonology
Rincon, Georgia, United States
ASHA Clinical Research - Munster, LLC
Hammond, Indiana, United States
Methodist Hospital Southlake
Merrillville, Indiana, United States
Paul A. Shapero, MD, PA
Bangor, Maine, United States
Revival Research Institute, LLC
Dearborn, Michigan, United States
Revive Research Institute, Inc.
Southfield, Michigan, United States
Henderson Clinical Trials
Henderson, Nevada, United States
Salem Chest Specialists
Winston-Salem, North Carolina, United States
Southeastern Research Center
Winston-Salem, North Carolina, United States
Toledo Institute of Clinical Research Inc.
Toledo, Ohio, United States
Clinical Research Associates of Central PA, LLC
DuBois, Pennsylvania, United States
Velocity Clinical Research, Gaffney
Gaffney, South Carolina, United States
Clinical Research of Rock Hill
Rock Hill, South Carolina, United States
Velocity Clinical Research, Spartanburg
Spartanburg, South Carolina, United States
Health Concepts
Rapid City, South Dakota, United States
Premier Research Center, LLC
Hendersonville, Tennessee, United States
Sherman Clinical Research
Sherman, Texas, United States
Dr. Syed Anees Medicine Professional Corporation
Windsor, Ontario, Canada
Nishifukuoka Hospital
Fukuoka, Fukuoka, Japan