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RECRUITING

NCT07363694

PHASE2/PHASE3

A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate to Severe Chronic Obstructive Pulmonary Disease

Sponsor: Pfizer

View on ClinicalTrials.gov

Summary

The purpose of this clinical trial is to learn about the effects and safety of the study medicine PF-07275315 for the potential treatment of COPD. COPD is a condition that makes it difficult to breathe, which negatively impacts the quality of life and functioning of people who are affected. This study is seeking participants who: * Are 35 to 80 years old * Have had moderate-to-severe COPD for at least 12 months * Have a documented history of at least 2 moderate or severe exacerbations within the last 12 months * Have been continuously taking their regular maintenance treatment(s) for COPD over at least 6 months at a stable dose for 3 months All participants will receive PF-07275315 or a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. PF-07275315 or placebo will be given as multiple shots in the clinic over the course of 24 weeks for the Phase 2 part and 52 weeks for the Phase 3 part. We will compare the results of people receiving PF-07275315 to those of the people who do not. This will help us determine if PF-07275315 is safe and effective. Participants who will be involved in the Phase 2 part of the study for about 40 weeks. During this time, they will have 11 visits at the study clinic. Participants who will be involved in the Phase 3 part of the study for about 68 weeks. During this time, they will have 18 visits at the study clinic.

Official title: AN INTERVENTIONAL PHASE 2/3, RANDOMIZED, DOUBLE-BLIND, THIRD PARTY-UNBLINDED, PLACEBO-CONTROLLED, PARALLEL-GROUP STUDY TO INVESTIGATE EFFICACY AND SAFETY OF PF-07275315 IN ADULT PARTICIPANTS WITH MODERATE-TO-SEVERE CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

Key Details

Gender

All

Age Range

35 Years - 80 Years

Study Type

INTERVENTIONAL

Enrollment

1156

Start Date

2026-02-11

Completion Date

2031-01-16

Last Updated

2026-06-17

Healthy Volunteers

Conditions

Moderate to Severe Chronic Obstructive Pulmonary Disease

Interventions

DRUG

PF-07275315 dose 1

SC injection dose 1

DRUG

PF-07275315-dose 2

SC injection dose 2

DRUG

Placebo

SC injection matched

DRUG

PF-07275315-dose 3

SC injection dose 3

Locations (87)

University of Alabama at Birmingham Lung Health Center

Birmingham, Alabama, United States

SEC Clinical Research

Dothan, Alabama, United States

Pulmonary Associates of Mobile, P.C.

Mobile, Alabama, United States

Chandler Clinical Trials

Chandler, Arizona, United States

Pulmonary Associates, PA

Phoenix, Arizona, United States

IMAX Clinical Trials

La Palma, California, United States

NewportNativeMD, Inc.

Newport Beach, California, United States

California Medical Research Associates

Northridge, California, United States

Institute of HealthCare Assessment d/b/a Apex Clinical Research

San Diego, California, United States

Finlay Medical Research

Greenacres City, Florida, United States

Clinical Research Specialists LLC

Kissimmee, Florida, United States

Advanced Pulmonary Research Institute

Loxahatchee Groves, Florida, United States

Reed Medical Research

Miami, Florida, United States

Renstar Medical Research

Ocala, Florida, United States

HCA Florida Ocala Imaging Center

Ocala, Florida, United States

Ocala Lung and Critical Care Associates

Ocala, Florida, United States

Coastal Medical Research Institute, LLC

St. Petersburg, Florida, United States

Coastal Pulmonary and Critical Care, P.L.C

St. Petersburg, Florida, United States

Clinical Site Partners, LLC dba Flourish Research

Winter Park, Florida, United States

Cpcc-Research Llc

East Point, Georgia, United States

Centricity Research Rincon Pulmonology

Rincon, Georgia, United States

ASHA Clinical Research - Munster, LLC

Hammond, Indiana, United States

Methodist Hospital Southlake

Merrillville, Indiana, United States

Southern Clinical Research, LLC

Zachary, Louisiana, United States

Paul A. Shapero, MD, PA

Bangor, Maine, United States

Revival Research Institute, LLC

Dearborn, Michigan, United States

AA Medical Research Center

Flint, Michigan, United States

Revive Research Institute, Inc.

Southfield, Michigan, United States

Washington University School of Medicine