Clinical Research Directory

Inclusion Criteria: 1. Age: Age ≥ 18 years old. 2. Diagnosis: Advanced unresectable intrahepatic cholangiocarcinoma (ICC) diagnosed by histology or imaging. 3. Measurable lesion: At least one measurable tumor lesion (according to RECIST 1.1 criteria). 4. Physical fitness status: The Eastern Cancer Collaboration Group (ECOG) physical fitness status score is 0 or 1. 5. Expected lifespan: Expected lifespan ≥ 3 months. 6. Liver function: Child Pugh classification A or B. 7. Organ function: It has sufficient organ function and laboratory tests meet the requirements of the protocol. 8. Not receiving relevant treatment: Not receiving systematic treatment for ICC. Exclusion Criteria: 1. Previous treatment: Previously received systemic treatment for ICC. 2. Poor physical condition: ECOG physical condition score ≥ 2. 3. Poor liver function: Child Pugh grading\>8. 4. Short life expectancy: Life expectancy is less than 3 months. 5. Merge with other malignant tumors: have other malignant tumors or a history of other malignant tumors. 6. Serious organ dysfunction: There is severe dysfunction in organs such as the heart, brain, lungs, and kidneys. 7. Drug allergy or intolerance: Allergic to the investigational drug or its excipients. 8. Other: Other situations that the researcher deems unsuitable to participate in this study