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Non-Invasive Preimplantation Genetic Screening for Aneuploidies and Clinical Outcomes in Egg Donation Patients
Sponsor: Instituto Bernabeu
Summary
Preimplantation genetic testing for aneuploidies (PGT-A) is commonly used in IVF but requires embryo biopsy and shows limited benefit in egg donation cycles. Non-invasive PGT-A (niPGTA), based on the analysis of cell-free embryonic DNA in spent culture media, offers a promising biopsy-free alternative. This prospective, blinded study in egg donation cycles will evaluate whether niPGTA-detected aneuploidy is associated with implantation failure and pregnancy loss, assessing its potential clinical value as a non-invasive embryo selection tool.
Official title: Non-invasive Preimplantation Genetic Screening (niPGTA) in Oocyte Donation Patients.
Key Details
Gender
FEMALE
Age Range
18 Years - 50 Years
Study Type
OBSERVATIONAL
Enrollment
164
Start Date
2026-02-26
Completion Date
2027-12-01
Last Updated
2026-01-23
Healthy Volunteers
Yes
Conditions
Locations (1)
Instituto Bernabeu
Alicante, Spain