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Analysis of the Presence and Cardiac Functional Effects of Anti-NaV1.5 Autoantibodies in Patients With Metastatic Tumors
Sponsor: IRCCS Policlinico S. Donato
Summary
The overall aim of this study is to identify and characterize anti-NaV1.5 autoantibodies in patients with metastatic breast and colorectal cancer. These tumors are characterized by the presence of a specific target structure (called nNaV1.5) against which antibodies are produced. These antibodies may cross-react with a similar structure (called NaV1.5) that is found in the heart. This could affect channel function and increase the risk of arrhythmias.
Key Details
Gender
All
Age Range
Any - Any
Study Type
INTERVENTIONAL
Enrollment
196
Start Date
2026-01
Completion Date
2026-12
Last Updated
2026-01-23
Healthy Volunteers
No
Conditions
Interventions
ECG
These patients require an ECG to exclude the onset of arrhythmias.
Locations (1)
IRCCS Policlinico San donato
Milan, Italy