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Clinical Characteristics, Frailty, and Prognostic Predictors in Patients Aged 75 and Older With Acute Coronary Syndrome
Sponsor: Clinical Center Niš
Summary
This study will evaluate clinical characteristics, frailty, and predictors of prognosis in patients aged 75 years and older who are hospitalized with acute coronary syndrome (ACS). The research includes both a retrospective and a prospective cohort. The aim is to determine whether frailty scores, combined with clinical and laboratory parameters available at admission, can improve risk prediction for complications and mortality compared with standard risk scores (TIMI, GRACE, Syntax). The study will also compare outcomes between patients treated with percutaneous coronary intervention (PCI) and those treated conservatively with medications. Patients will be followed during hospitalization and for six months after discharge. The results are expected to contribute to more personalized treatment strategies for elderly patients with ACS.
Official title: Investigation of Clinical Characteristics, Frailty, and Predictors of In-Hospital and Six-Month Prognosis in Hospitalized Patients Aged 75 Years and Older With Acute Coronary Syndrome
Key Details
Gender
All
Age Range
75 Years - Any
Study Type
OBSERVATIONAL
Enrollment
550
Start Date
2026-03
Completion Date
2027-06
Last Updated
2026-01-26
Healthy Volunteers
No
Conditions
Interventions
Percutaneous Coronary Intervention (PCI)
Patients receiving PCI as part of routine clinical care
Conservative Medical Therapy
Patients treated conservatively with guideline-directed medical therapy as part of routine care
Locations (1)
Clinical Center Niš
Niš, Serbia