Clinical Research Directory
Browse clinical research sites, groups, and studies.
Neuropathic Pain in Knee Osteoarthritis: Pain Severity and Functional Status
Sponsor: Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Summary
Osteoarthritis (OA) is a degenerative joint disease characterized by structural changes such as cartilage loss and osteophyte formation, leading to functional limitations and disability. Pain in knee OA involves a complex pathophysiological structure including both nociceptive and neuropathic mechanisms. Identifying the neuropathic pain component is clinically significant for improving quality of life and functional recovery. This cross-sectional controlled clinical study aims to determine the prevalence of neuropathic pain in patients with knee OA and evaluate its impact on pain severity and functional status. Patients will be categorized based on the Douleur Neuropathique 4 (DN4) questionnaire and assessed using various pain and functional scales.
Official title: Presence of Neuropathic Pain in Knee Osteoarthritis: Relationship Between Pain Severity and Functional Status
Key Details
Gender
All
Age Range
40 Years - 70 Years
Study Type
OBSERVATIONAL
Enrollment
102
Start Date
2025-12-20
Completion Date
2026-04-30
Last Updated
2026-01-26
Healthy Volunteers
No
Conditions
Interventions
Clinical and Functional Assessment
All participants will undergo a one-time, cross-sectional clinical assessment. Comprehensive demographic and clinical data, including age, body mass index (BMI), educational level, occupation, and marital status, will be recorded for each participant. Pain intensity will be measured using a 10-cm Visual Analog Scale (VAS). Functional status and symptoms related to knee osteoarthritis will be evaluated using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the Knee Injury and Osteoarthritis Outcome Score-Physical Function Short Form (KOOS-PS). To ensure consistency and minimize measurement error, all anthropometric measurements, specifically weight and height, will be performed by the same researcher.
Locations (1)
Istanbul Physical Medicine and Rehabilitation Training and Research Hospital
Istanbul, Turkey (Türkiye)