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Assessment Of Guided Bone Regeneration Using Xenograft Mixed With Allogenic Bone Graft Versus Xenograft Mixed With Autogenous Graft For Augmentation Of Maxillary Alveolar Ridges
Sponsor: Cairo University
Summary
This study aims to evaluate the effect of Allogenic bone graft mixed with Xenograft in ratio 1:1, on the radiographic and histomorphometric assessment versus Autologous bone graft mixed with Xenograft in ratio 1:1 in maxillary deficient ridges، In guided bone regeneration of deficient edentulous maxillary ridges, will the application of Xenograft mixed with Allograft (1:1) be as effective as Xenograft mixed with Autogenous graft (1:1) in terms of dimensional ridge changes and Quality of newly formed bone? Evaluation of the patient's general condition of the oral cavity, to make sure it complies with the criteria required to be enrolled in the study in terms of oral hygiene and pathological conditions. A full thickness flap will be elevated with two releasing incisions, decortication of the buccal aspect of the ridge, placing of grafting material which will be covered by collagen pericardium membranes, tacks placement at the labial side to fix the membrane in place, horizontal mattress sutures as well as single interrupted and continuous with resorbable sutures for closure. Intervention group: will be filled with mixture of Xenogenic graft and the Allogenic bone graft chips. Control group: will be filled with mixture of Xenogenic graft and Autogenous bone particulate harvested either from the mandibular symphysis or ramus. For both groups, All the subjects will be taking CBCT at pre surgical and 6 months post surgical. outcomes : Bucco-Palatal/Lingual horizontal bone gain, Alveolar ridge height,Percentage of new vital bone formation and Percentage of residual bone graft 6 months post-surgical.
Official title: Radiographic And Histomorphometric Assessment Of Guided Bone Regeneration Using Xenograft Mixed With Allogenic Bone Graft Versus Xenograft Mixed With Autogenous Bone Graft For Augmentation Of Deficient Maxillary Alveolar Ridges A Randomized Clinical Trial
Key Details
Gender
All
Age Range
20 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
32
Start Date
2024-06-01
Completion Date
2026-06-01
Last Updated
2026-01-28
Healthy Volunteers
Yes
Conditions
Interventions
Allogenic bone graft mixed with Xenograft in ratio 1:1
Xenogenic graft is then to be mixed in equal 1:1 volume of particles size 0.25-1 mm with the Allogenic bone graft chips to create 1:1 composite graft.
Autologous bone graft mixed with Xenograft in ratio 1:1
Autogenous bone particulate will be harvested either from the mandibular symphysis or ramus. Mandibular symphysis as a donor site: A beveled partial to full thickness muco-periosteal incision 5 to 10 mm below the muco-gingival junction will be performed at the symphyseal region to expose the donor site. The incision extended just distal to the mandibular canines to allow for adequate access and easier adaptation of the flap.Mandibular ramus as a donor site: A submarginal incision will be placed within the keratinized mucosa opposite to the lower first molar and extending 1 cm along the ramus of the mandible.
Locations (1)
Faculty of Dentistry Cairo University
Cairo, Egypt