Clinical Research Directory

Inclusion Criteria: * Medically fit young adults * The patient should have mild to moderate crowding or spacing of teeth. * The treatment plan should be non-extraction. * Patients should have optimum oral hygiene before beginning the treatment. * The patient may have a maximum of three teeth with either fillings or dental prostheses. (According to the British national institute of health, NIH 2016). Exclusion Criteria: * Patients with defective enamel, generalized enamel disorder, or extensive dental restorations. * Patients with syndromes or orofacial anomalies. * Patients with salivary gland diseases or taking medications that may affect oral flora or salivary functions. * Patients who are pregnant or diabetic. * Patients use mouth rinses or any extra form of fluoride other than toothpaste.