Clinical Research Directory

Inclusion Criteria: * Suspicion of a local prostate cancer * Patient have 1-2 PI-RADS 3-5 lesion/lesions in biparametric prostate MRI, with no ISUP 2-5 prostate cancer in an initial systematic or lesion-targeted (at least two biopsy cores per lesion) biopsy * Prostate biopsies can be taken via transrectal approach in an outpatient clinic * An estimated life expentancy exceeding 10 years * The patient is cooperative, fluent in Finnish and understands the significance of the study * The patient signs an informed consent form approved by the ethics committee. Exclusion Criteria: * The patient had undergone prostate biopsies prior to the biopsies that led to recruitment for the current study. * The physician's suspicion of a locally advanced or a high risk prostate cancer. Absolute exclusion criteria are PSA \>20 ng/ml or T4 staged prostate finding MRI or clinical examination * Seriuos infectious or non-infectious complication after initial biopsy * Deep immunosuppression due to organ transplant, hematologic disease, or related causes. * Any treatment given for prostate cancer diagnosed in initial biopsy * Hip prosthesis or any other object in the pelvic area that affects high-quality MRI * Claustrophobia or other absolute or relative contraindication for high-quality MRI