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The Analgesic Efficacy and Safety of Flurbiprofen Patch in Patients With Herpes Zoster
Sponsor: Beijing Tiantan Hospital
Summary
Herpes zoster (HZ) is characterized by a painful dermatomal rash and significantly affects quality of life, with acute pain increasing the risk of postherpetic neuralgia. Although early antiviral therapy limits viral replication, its analgesic effect is insufficient, and many patients experience inadequate relief despite stepwise use of non-opioids and opioids. Topical NSAIDs offer a promising alternative by delivering localized analgesia with reduced systemic exposure. Therefore, investigators hypothesize that flurbiprofen patch may effectively reduce the severity of HZ pain without significantly increasing adverse events.
Official title: The Analgesic Efficacy and Safety of Topical Patches (Flurbiprofen Patch) in Patients With Herpes Zoster
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
750
Start Date
2025-12-15
Completion Date
2027-12-31
Last Updated
2026-01-27
Healthy Volunteers
No
Conditions
Interventions
Flurbiprofen patch combined with conventional therapy group
In the flurbiprofen patch combined with conventional therapy group, apply the patch to the painful point near the herpes lesion. Use one patch per day, twice a day. In addition, the group will contain conventional treatment for HZ, except flurbiprofen patch, including opioids, antiviral drugs and so on.
Conventional therapy group
In the conventional therapy group, treatments will include opioids, antiviral drugs and so on.
Locations (1)
Beijing Tiantan Hospital, Beijing, Beijing 100070
Beijing, China