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Effect Of Three Remineralizing Agents On Early Childhood Caries
Sponsor: University of Jazan
Summary
Early Childhood Caries (ECC) remains a global public health concern, necessitating minimally invasive, fluoride-based alternatives to conventional restorative therapy. Silver Diamine Fluoride (SDF), Sodium Fluoride with Casein Phosphopeptide-Amorphous Calcium Phosphate (NaF + CPP-ACP), and Acidulated Phosphate Fluoride (APF) gel are widely employed chemotherapeutic agents; however, comparative clinical evidence of their effectiveness in ECC management remains limited. This randomized controlled clinical trial will evaluate and compare the efficacy of SDF gel, NaF + CPP-ACP, and APF gel in arresting and preventing ECC.
Official title: Effect Of Silverdiamine Fluoride Gel, Sodium Fluoride With CPP-ACP, APF On Early Childhood Caries - A Randomised Controlled Trial
Key Details
Gender
All
Age Range
2 Years - 9 Years
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2025-11-01
Completion Date
2026-02-25
Last Updated
2026-09-10
Healthy Volunteers
No
Interventions
Silver Diamine Fluoride (SDF, 38%)
Silver diamine fluoride gel is applied in gel form
Sodium Fluoride with CPP-ACP
This is in a Topical fluoride varnish
Acidulated phospahate fluoride gel 1.23%
This is a topical fluoride application for 1 minute application
Locations (1)
College of Dentistry, jazan University
Jizan, Jazan Region, Saudi Arabia