Clinical Research Directory

Inclusion Criteria: * Women or men, * aged \>18 and ≤ 65, * French-speaking, * active alcohol users (as defined by the criteria in the Diagnostic and Statistical Manual of Mental Disorders, 5th edition, DSM-5) * who agree to be hospitalized for alcohol withdrawal for a period of 7 days * Affiliated with or eligible for social security. * Negative pregnancy test (for patients of childbearing age) Exclusion Criteria: * any other addictive disorder (except tobacco), * inflammatory bowel disease or any other chronic inflammatory disease, * current cancer, * metabolic diseases such as obesity (BMI ≥ 30 kg/m²) kg/m2) or a history of bariatric surgery, * severe cognitive impairment (MMSE \< 24), * psychiatric comorbidities including suicide risk, * cirrhosis or significant fibrosis (≥F2) defined by a Fibroscan value \>7.6 kPa, * pregnancy or breastfeeding, * taking antibiotics, probiotics, or prebiotics in the 2 months prior to inclusion, * taking non-steroidal anti-inflammatory drugs or glucocorticoids in the month prior to inclusion. * taking baclofen, disulfiram, naltrexone, or acamprosate. * Participation in another interventional study involving human subjects or being in the exclusion period following a previous study involving human subjects, if applicable * Patients under AME * Patients under guardianship, trusteeship, or any other legal protection measure