Clinical Research Directory
Browse clinical research sites, groups, and studies.
The Efficacy and Safety of Intramuscular Methylprednisolone in Patients With Hand OsteoArthritis
Sponsor: Sint Maartenskliniek
Summary
The goal of this clinical trial is to determine the efficacy and safety of intramuscular methylprednisolone in patients with hand osteoarthritis. The main question it aims to answer is what the difference is in hand pain 4 weeks after the first injection with methylplrednisolone. This main goal will be assessed in the first 16 weeks, the RCT phase. Researchers will compare 120mg methylprednisolone with 40mg methylprednisolone and placebo to see if there is a difference in hand pain after 4 weeks. Participants will be asked to visit the hospital for: * injection of the study material * ultrasound assessment * physical examination like joint assessments and grip strenght * examination of blood * x-ray of the hand In phase 2, from week 16 to 48, an open label phase focusing on treatment strategy and safety. In this phase all participants may receive intramuscular methylprednisolone on demand at the dosage of 120mg only if they fulfil the following conditions: hand pain \> 30mm on a VAS (0-100mm) and a minimum of 16 weeks interval between two consecutive injections. Therefore, a maximum of two injections could be received during this period. Irrespective of that, all participants will be followed-up until week 48 when the end-of-study visit will take place.
Official title: The Efficacy and Safety of Intramuscular Methylprednisolone in Patients With Hand OsteoArthritis - the IMHOA Trial
Key Details
Gender
All
Age Range
16 Years - Any
Study Type
INTERVENTIONAL
Enrollment
212
Start Date
2025-10-28
Completion Date
2028-11
Last Updated
2026-01-28
Healthy Volunteers
No
Conditions
Interventions
120mg methylprednisolone acetate
One single intramuscular injection with 120mg methylprednisolone will be administered at baseline to each participant in the first phase. During the second phase, participants may receive intramuscular methylprednisolone on demand at the dosage of 120mg only if they fulfil the following conditions: hand pain \>30mm on a VAS (0-100mm) and a minimum of 16 weeks interval between two consecutive injections.
40mg methylprednisolone acetate
One single intramuscular injection with 40mg methylprednisolone will be administered at baseline to each participant in the first phase.
Placebo
One single intramuscular injection of placebo (NaCl 0.9%) will be administered at baseline to each participant in this phase.
Locations (1)
Sint Maartenskliniek
Ubbergen, Gelderland, Netherlands