Clinical Research Directory

Inclusion Criteria: * Adult patients undergoing middle ear surgery including tympanoplasty with or without ossicular chain reconstruction, tympanomastoidectomy or stapedectomy * Patient using a hormonal contraceptive will be included, but warned aprepitant may reduce the efficacy of hormonal contraception thus an alternative or backup contraceptive methods should be used for one month after surgery Exclusion Criteria: * Children (\<18 years old) * Patients unable to complete the post-procedure questionnaire (either due to time constraints, neurocognitive impairment, etc.) * Patients taking concomitant medications that are substrates, inhibitors or inducers of CYP3A4 or CYP2CP that are at risk of having a clinically significant effect * Patients with a history of hypersensitivity reaction to any of the medications used in the study * Patients who are pregnant or breastfeeding * Patients unable to receive general anesthesia (i.e. procedures performed under local anesthesia with or without sedation) * Patients with severe hepatic insufficiency (Child-Pugh class C) * Patients on total intravenous anesthesia (TIVA)