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Ultrasound Liver Imaging for Classification of Metabolic Dysfunction-associated Steatotic Liver Disease
Sponsor: University of British Columbia
Summary
Tissue elasticity and viscosity correlate with pathology. These tissue properties are typically evaluated subjectively using palpation. The purpose of "elastography" is to provide an objective elasticity image that is equivalent to the remote palpation of tissue. The investigators have developed elastography imaging systems based on ultrasound and magnetic resonance imaging and have applied them previously to prostate imaging, breast imaging in patients and liver imaging in healthy volunteers. A first objective of this study is to compare the investigators' ultrasound shear wave absolute vibro-elastography (S-WAVE) technology with the existing clinical standard, FibroScan, and magnetic resonance elastography to quantify liver stiffness in healthy volunteers and in patients suspected of fatty liver disease. A second objective of this study is to compare ultrasound-based liver tissue fat measurement with MRI-based measurements. A third objective of this study is to determine whether ultrasound can be used to assess liver inflammation.
Official title: Multi-modal, Multi-parametric Liver Imaging for Ultrasound-based Stratification of Patients With MAFLD
Key Details
Gender
All
Age Range
19 Years - 75 Years
Study Type
OBSERVATIONAL
Enrollment
145
Start Date
2026-01-01
Completion Date
2032-07-01
Last Updated
2026-01-28
Healthy Volunteers
Yes
Interventions
Ultrasound and magentic resonance imaging
For each healthy volunteer and patient, there will be two sessions of imaging. Magnetic resonance imaging, including proton density fat fraction (PDFF) and elastography (MRE) will be acquired. Multi-paramteric, volumetric ultrasound will also be acquired, including shear wave absolute elastography and attenuation, as well as raw radio-frequecy (echo) data. Two systems, a Philips Epiq and a Sonic Incytes Velacur will be used to acquire ultrasound images, including elasticity and attenuation. In addition, Fibroscan measurements (Liver Stiffness measurement and Controlled Attenuation Parameter) will be acquired.
Locations (1)
University of British Columbia
Vancouver, British Columbia, Canada