Clinical Research Directory

Inclusion Criteria: * Healthy patients aged at least 18 years old with deep or extremely deep carious lesions in mature permanent teeth diagnose with symptomatic irreversible pulpitis. Diagnoses are confirmed using EPT and cold tests. Pulpal and periapical diagnoses are based on terminology from the American Association of Endodontists (AAE, 2013)20. * Posterior teeth with moderate or severe pain according to The NRS (Numeric Rating Scale) According to this scale, the level of pain is documented in the range of 0-10 numerically and verbally as no pain (0), mild pain, non-disruptive to routine activities (1-3), moderate pain that interferes with daily life but no need analgesics intake (4-6) and severe pain that significantly disrupts normal acitivities requiring analgesic intervention (7-10). * Teeth that response negatively to percussion and palpation tests. * Teeth are restorable with direct composite restoration. Exclusion Criteria: * Teeth with subgingival caries and/or clinical attachment loss more than 3 mm and probing depth more than 4 mm. * Negative responses to pulp sensibility tests, presence of sinus tracts, swelling, non-restorable crowns, immature roots, or no pulp exposure following complete caries removal in case of pre-operative diagnosis as asymptomatic irreversible pulpitis. * Patients with systemic diseases involving bleeding disorders such as hemophilia, Von Willebrand disease, platelet disorders. And patients under taking all kind of anticoagulant and anti-platelet. * Patients who had taken analgesics or anti-inflammatory drugs within the previous 24 hours. If necessary, record how many and dose that taken. * Patients taking opioids. * Known allergies to non-steroidal anti-inflammatory drugs (NSAIDs). * Pregnant or lactating patients. * Teeth with pulpal obliteration. * Necrotic pulp is found after access opening * Bleed cannot be stopped within 8 minutes after full pulpotomy