Clinical Research Directory

Inclusion Criteria: * Participants must have completed at least two consecutive physical examinations at the Physical Examination Center of Beijing Friendship Hospital, Capital Medical University, between June 2007 and August 2025, with a minimum interval of 6 months between adjacent records. * Data records should be relatively complete, with missing rates for key research variables (e.g., core biochemical indicators, demographic information, and essential questionnaire items) ≤30%. * Participants must have no prior history of severe organic diseases prior to their first study inclusion (as documented in medical records, primarily including: malignant tumors (non-curable/end-stage), severe cardiac insufficiency (NYHA Class III-IV), end-stage renal disease (CKD Stage 5), decompensated cirrhosis, or significant functional impairment caused by sequelae of severe cerebrovascular disease). Exclusion Criteria: \- Individuals with a severe lack of basic data (such as unique identification, key demographic information, and core indicators of detection) or who cannot be effectively anonymized.