Clinical Research Directory

Inclusion Criteria: * Age between 40 and 60 years * Participants falling under stages -2 to +2 in the Stages of Reproductive Aging Workshop (STRAW +10) as defined below: * Early menopause transition (Stage -2): Increased variability in menstrual cycle defined as persistent difference of 7 days or more in the length of consecutive cycles. Persistence is defined as recurrence within 10 cycles of the first variable cycle. * Late menopause transition (Stage -1): Occurrence of amenorrhea of 60 days or longer. * Final Menstrual Period (Stage 0): Have undergone 12 consecutive months without a menstrual period, not due to other medical causes. * Early Postmenopause (Stage +1): 5-8 years after final menstrual period. * Late Postmenopause (Stage +2): \>8 years after final menstrual period. * Participants having frequent hot flashes (at least once a day). Exclusion Criteria: * Disorders that may mask or coincide with menopause and peri-menopause, such as: Primary Ovarian Insufficiency, Thyroid disease (Hyper/hypothyroidism), Hyperprolactinemia, Cushing's syndrome, Endometrial/Ovarian Cancer, Polycystic Ovary Syndrome (PCOS), Functional hypothalamic amenorrhea * Concurrent drugs: * GnRH agonist/antagonist * Tamoxifen/aromatase inhibitors * Other conditions: Recent hematoma (\<48 hours), History of hemorrhagic disorders (any platelet disorder (ITP, TTP, HUS, Glanzmann thrombasthenia), Hemophilia A/B, history of arterial insufficiency, any prior history of malignancy, current pregnancy, a lifetime history of severe, uncontrolled mood disorders (anxiety, depression, bipolar), psychotic disorders, other neural disorders, or heart disease, any condition that makes them unable to perform tasks outlined in experiment, tattoos on sensory testing sites.