Clinical Research Directory

Inclusion Criteria: * Aged ≥18 years * Diagnosed with type 2 diabetes * HbA1c between 6.5-12.0% * Fasting C-peptide level ≥0.5 ng/ml, indicating the patient does not have beta-cell failure, as measured at screening Exclusion Criteria: * On insulin * Evidence of latent autoimmune diabetes (LADA) or maturity-onset diabetes of the young (MODY) * Estimated glomerular filtration rate (eGFR) \<45 ml/min per 1.73 m² * Heart attack in the past 6 months or severe/unstable heart failure * On weight loss medication, including GLP-1 receptor agonists (e.g., semaglutide, dulaglutide) * Change in the dosage of a chronic medication that may affect study endpoints within the past 3 months * Clinically significant laboratory abnormality (e.g., abnormal hemoglobin levels) * Significant gastrointestinal disease, major gastrointestinal surgery, or gallstones * Significant cardiovascular, renal, cardiac, liver, lung, adrenal, or nervous system disease that might compromise participant safety or data validity * Evidence of cancer (other than non-melanoma skin cancer) within the last 5 years * Lost or gained more than 5 lbs (or more than 2% of body weight if the patient weighs \>250 lbs) of weight in the past 2 months * Pregnant, planning to become pregnant in the next 6 months, or breastfeeding * Major psychiatric condition that would affect the ability to participate in the study * Not able to eat the provided study meals (e.g., food allergies) * Behavioral factors or circumstances that may impede adherence to the dietary intervention * Not able to undergo the MRI scan (e.g., due to claustrophobia, implanted metal objects, or body girth ≥60 cm)