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Combination Antibiotic Therapy for Staphylococcus Aureus Bacteremia
Sponsor: Intermountain Health Care, Inc.
Summary
The purpose of this study is to see if, in selected patients with a serious bacterial infection of the bloodstream, treating the bacterial infection with a combination of antibiotics is more effective than treating the infection with a single antibiotic. Participants must have blood cultures which are positive for a certain type of bacteria.
Official title: COMBAT-SAB: Combination Antibiotic Therapy for Staphylococcus Aureus Bacteremia
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
2096
Start Date
2026-02-01
Completion Date
2029-01
Last Updated
2026-01-29
Healthy Volunteers
No
Conditions
Interventions
Antibiotic Monotherapy (AM) for patients with methicillin-sensitive S. aureus bacteremia (MSSAB)
Intravenous anti-staphylococcal beta-lactam, either cefazolin or nafcillin, per the discretion of the treating physician.
Antibiotic Monotherapy (AM) for patients with methicillin-resistant S. aureus bacteremia (MRSAB)
Vancomycin or daptomycin, per discretion of the treating physician
Combination Antibiotic Therapy (CAT) for patients with methicillin-sensitive S. aureus bacteremia (MSSAB)
Patients with methicillin-sensitive S. aureus bacteremia (MSSAB) and no contraindications will receive an anti-staphylococcal beta-lactam, either cefazolin or nafcillin, plus ertapenem
Combination Antibiotic Therapy (CAT) for patients with methicillin-resistant S. aureus bacteremia (MRSAB)
Daptomycin plus ceftaroline
Locations (13)
Platte Valley Hospital
Brighton, Colorado, United States
Saint Joseph Hospital
Denver, Colorado, United States
St. Mary's Regional Hospital
Grand Junction, Colorado, United States
Good Samaritan Hospital
Lafayette, Colorado, United States
Lutheran Medical Center
Wheat Ridge, Colorado, United States
St. Vincent Regional Hospital
Billings, Montana, United States
St. James Hospital
Butte, Montana, United States
Holy Rosary Hospital
Miles City, Montana, United States
Intermountain Medical Center
Murray, Utah, United States
McKay-Dee Hospital
Ogden, Utah, United States
Utah Valley Hospital
Provo, Utah, United States
LDS Hospital
Salt Lake City, Utah, United States
St. George Regional Hospital
St. George, Utah, United States